Diabetes of the Brain Connected to Alzheimer's

A new form of diabetes, called type 3 or "brain diabetes," is being investigated and may have more in common with Alzheimer's than was suspected. A new study from the National Institute of Aging shows high glucose concentrations in brain tissue correlating with characteristics of Alzheimer's. The study was led by the Institute's Laboratory for Behavioral Neuroscience.

The study shows how high glucose concentrations in brain tissue may result from abnormal glucose metabolism. This could eventually lead to the dangerous senile plaques and tangles that are characteristics of Alzheimer's, the study's authors say.

The study sets the stage for future studies that could uncover interventions targeting brain glucose and type 3 diabetes.

The study describes how glucose levels are metabolized in the brain through a process that does not involve insulin. A key protein, GLUT3, transports the glucose through the metabolic process into nerve cells. There, it undergoes glycolysis, producing energy for brain cells.


With diabetes, high fasting blood sugar levels are common. This, the study learned, translates into higher concentrations of brain-tissue glucose levels. Other Alzheimer conditions include high inflammation and oxidative stress, also found in patients with type 3 diabetes.

Source: Post-Gazette.com


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