Prediabetes increases cancer risk by 15 percent
Having prediabetes increases the risk for cancer by 15 percent, according to a new study published in Diabetologia.
The research included a meta-analysis of 16 studies and over 890,000 participants from various regions across the world.
Prediabetes, which refers to the stage between having normal blood sugar levels and full-blown diabetes, includes compromised glucose tolerance, impaired fasting glucose, or a combination of the two.
Researchers found that prediabetes was associated with a 15 percent increased risk of cancer in general, and the link was strong regardless of adjustments made for age, ethnicity, obesity, or duration of cancer.
Explaining the link
A few possible reasons for the diabetes-cancer connection could exist, the authors said. Chronic hyperglycaemia could cause carcinogenic factors, while excess insulin secretion could also enable cancer cells to grow and divide.
The authors note that metformin, a common diabetes medication, is now thought to have properties that can protect against cancer, but research is unclear on whether this type of drug would be helpful in preventing cancer in people with prediabetes.
"Considering the high prevalence of prediabetes, as well as the robust and significant association between prediabetes and cancer demonstrated in our study, successful intervention in this large population could have a major public health impact," the authors wrote.
Source: Science Daily
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